Fat burners, diet aids, weight loss support supplements -- whatever you want to call them -- come in all different shapes and sizes.
Some are nothing other than glorified caffeine pills while others, like Apollon Nutrition’s CHAOS, take a more comprehensive and refined approach that not only helps boost energy, but also helps enhance the body’s natural fat burning mechanisms.
Today, we take a closer look at one of the newest additions to the latest edition of CHAOS in InnoSlim® -- an all-natural plant extract known to encourage weight loss, reduce appetite, and improve fat metabolism.
What is InnoSlim?
InnoSlim® is an all-natural ingredient derived from Panax Notoginseng and Astragalus that supports long-term weight loss.
This novel weight loss ingredient was developed by NuLiv Science and has been shown in clinical trials to :
- Encourage fat burning
- Reduce appetite
- improve glucose absorption by skeletal muscle
- Decrease glucose absorption in the gut
- Enhance fatty acid breakdown in adipocytes (fat cells)
What Does InnoSlim Do?
The two main benefits attributed to InnoSlim are:
- its ability to reduce the amount of calories the body absorbs, and
- The calories that it does absorb are more efficiently absorbed into muscle and fat cells, prompting an increase in adiponectin (more on this down below!)
Additional in vitro studies performed by NuLiv Science indicate that InnoSlim may help :
- Reduce glucose absorption up to 42% (using CaCO 2 cells) 
- Decrease calorie intake via downregulation of SGLT1 
- Increase glucose uptake in skeletal muscle cells 
- Increase fatty acid breakdown in fat cells 
- Increase AMPK activation in skeletal muscle cells by 23% 
Decrease markers of inflammation and insulin-resistance 
How Does InnoSlim Work?
Increases Energy Expenditure
To understand how InnoSlim can help boost energy expenditure, it helps to have a rudimentary understanding of a couple “big players” that affect energy homeostasis in the body.
First up is a hormone that is secreted by fat cells called adiponectin. Researchers have identified it as a key regulator of insulin sensitivity and inflammation in the body. [2,3]
InnoSlim and Adiponectin
Adiponectin impacts skeletal muscle tissue as well as the liver and the vascular system where it helps enhance insulin sensitivity and fuel burning (via up-regulation of AMPK activity) as well as reduce inflammation in the vasculature. 
Furthermore, this multifaceted hormone can also attenuate (reduce) the accumulation of triglycerides in skeletal muscle tissue.
Due to its anti-diabetic, anti-inflammatory, and anti-atherogenic effects, adiponectin has also been identified as a target for certain chronic lifestyle diseases, including type 2 diabetes and metabolic syndrome.
Under normal circumstances (i.e a healthy body fat level), adiponectin secretion is fine and it does its job efficiently. However, as body fat levels increase, adiponectin secretion and concentration in the blood declines. [2,3]
This drop in adiponectin plays a pivotal role in several obesity-related diseases.
Now, here’s where InnoSlim comes into the picture.
InnoSlim has been documented to increase adiponectin secretion from fat cells up to 103%.
Additionally, InnoSlim has also been noted to reduce inflammatory biomarkers TNF-α, PAI-1, and RBP4, which can impair normal adiponectin secretion.
Researchers noted that increased adiponectin secretion resulted in greater glucose utilization in skeletal muscle as well as increased fatty acid oxidation in muscle and liver tissues.
As a result of increased adiponectin release, AMPK activity increased in skeletal muscle (up to 23%!).
Why is this important?
AMPK (AMP-activated protein kinase) is an enzyme found in every single cell of our body, that serves as a “master regulator” switch for energy production. It also impacts growth.
AMPK is activated by specific stressors that increase the ratio of AMP (adenosine monophosphate) to ATP (the cellular currency of energy production).
Examples of these “stressors”, include :
- Exercise -- which uses ATP to power muscle contractions
- Glucose deprivation (i.e. fasting or very-low carb/ketogenic diets)
As the body enters this low ATP state, AMPK initiates a series of reactions that boost ATP production, including glucose transport and fatty acid oxidation (aka “fat burning”).
Additionally, activation of AMPK also has a tendency to tap the brakes on ATP-consuming processes including cellular growth and protein synthesis (muscle growth and recovery).
Because of this action, it may be wise to limit AMPK-activating compounds (like berberine) in the peri-workout timeframe, lest you unknowingly impede muscle growth and/or recovery.
Now, as you’re likely aware, as you age a number of things (hormone production, libido, muscle growth/recovery) start to decline.
Activation of AMPK is no exception. It too declines as we age, which can impair the body’s ability to burn fat efficiently.
Studies suggest that InnoSlim may help attenuate this decline AMPK activity.
Moreover, greater AMPK activity encourages fat burning in the liver and skeletal muscle tissue while also helping limit production of triglycerides, cholesterol, and fat.[1,7]
Increased Glucose Utilization
AMPK activation also causes the activation of GLUT4 -- the main insulin-regulated glucose transporter for skeletal muscles and fat tissue.
Increased GLUT4 activity supports greater glucose uptake by skeletal muscles which helps lower blood sugar levels.
Additionally, increased GLUT4 activity also increases phospho-ACC -- an enzyme that inhibits fatty acid formation.
In vitro studies note that InnoSlim increases glucose utilization in muscle and fat cells.
The end result of this physiological cascade is increased calorie expenditure, which supports weight loss.
Decrease Energy Intake
In addition to increasing energy expenditure, InnoSlim may also help reduce energy (calorie) intake.
This occurs as a result of the downregulation of the SGLT1 protein and mRNA expression levels in the intestines.
SGLT1 stands for sodium-dependent glucose transporter-1, and it mediates glucose absorption in the intestines.[8,9]
Less SGLT1 activity means that less glucose is absorbed in the gut, which subsequently reduces energy intake.
Another big benefit of decreased glucose absorption in the gut is lower blood glucose levels, and as a result, lower insulin levels.
To top it off, InnoSlim also may also help reduce appetite by lowering blood glucose levels in the and increasing insulin activity, which again helps reduce total daily energy intake, thereby supporting weight loss and weight management goals.
InnoSlim is a novel ingredient that attacks the problem of weight loss from multiple avenues.
It helps increase energy expenditure while at the same time reducing energy intake, providing a two-pronged approach to help individuals lose weight.
- InnoSlim Product Dossier
- Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017;18(6):1321. Published 2017 Jun 21. doi:10.3390/ijms18061321
- Whitehead, J. P., Richards, A. A., Hickman, I. J., Macdonald, G. A., & Prins, J. B. (2006). Adiponectin--a key adipokine in the metabolic syndrome. Diabetes, Obesity & Metabolism, 8(3), 264–280. https://doi.org/10.1111/j.1463-1326.2005.00510.x
- Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13(9):1016–1023. Published 2011 Sep 2. doi:10.1038/ncb2329
- Huang, S., & Czech, M. P. (2007). The GLUT4 glucose transporter. Cell Metabolism, 5(4), 237–252. https://doi.org/10.1016/j.cmet.2007.03.006
- Richter, Erik A., and Neil B. Ruderman. "AMPK and the biochemistry of exercise: implications for human health and disease." Biochemical Journal, vol. 418, no. 2, 2009, pp. 261-275.
- Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016;48(7):e245. Published 2016 Jul 15. doi:10.1038/emm.2016.81
- Du, F., Hinke, S. A., Cavanaugh, C., Polidori, D., Wallace, N., Kirchner, T., … Hornby, P. J. (2018). Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents. Journal of Pharmacology and Experimental Therapeutics, 365(3), 676 LP – 687. https://doi.org/10.1124/jpet.118.248575
- Röder PV, Geillinger KE, Zietek TS, Thorens B, Koepsell H, Daniel H. The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014;9(2):e89977. Published 2014 Feb 26. doi:10.1371/journal.pone.0089977
- InnoSlim Overview. NuLiv Science