The world of nootropics is as vast as it is complex. And, as our understanding of the human brain grows with each passing day, so too does the pool of nootropics from which we can dabble and experiment. Today, we zero in on one of the most potent nootropics of all -- Noopept.
If you’ve tried our ultra-premium nootropic supplement, Overtime, you have first hand experience with the pure potency of this fascinating molecule. But, chances are pretty good that you might not really know what noopept is or what it does. That’s where this quick-hits guide comes in. We’ll give you everything you need to know about Noopept, and why it’s one of the best nootropics available!
Let’s start by answering a simple question…
What is Noopept?
In simple terms, noopept is a powerful, fast-acting nootropic with notable cognitive enhancement and neuroprotective properties.[1,2,3]
It’s similar in structure to Piracetam (the granddaddy of all nootropics), but research indicates that noopept is up to 1,000 times more potent!
Noopept readily crosses the blood-brain barrier, and reaches peak concentration after just 15 to 20 minutes.
How Does Noopept Work?
Researchers are still working to determine the exact mechanisms of action of Noopept, but it is believed to amplify acetylcholine activity in the body. The reason this is noteworthy is that acetylcholine is known as the “learning transmitter” due to its impact on learning. It’s also involved in memory, cognition, and the mind-muscle connection. Noopept has also been shown to upregulate the expression of both NGF and BDNF, two important brain proteins that impact cognition and memory.
Animal models also indicate that noopept modulates both the AMPA and NMDA receptors, helping to prevent glutamate toxicity, while also enhancing neuroplasticity. Noopept is also known as a powerful neuroprotectant due to its anti-inflammatory and antioxidant properties.
Benefits of Noopept
Increases Levels of BDNF & NGF
Brain-Derived Neurotrophic Factor (BDNF) is a protein that supports the survival of existing neurons, and promotes the growth and differentiation of new neurons and synapses. It’s primarily active in the hippocampus, cortex, and basal forebrain -- regions of the brain heavily impacting learning, memory, and higher thinking.
Nerve Growth Factor (NGF) is another neurotrophic factor, similar to BDNF, that impacts the growth, maintenance, and survival of nerve cells, including neurons (brain cells). NGF also plays a big role in neurogenesis -- the creation of new neurons.
Animal studies have found that Noopept is able to stimulate the expression of these two highly important brain-boosting chemicals.
Enhances Memory and Learning
Seeing as noopept increases the activity of both NGF and BDNF -- two neurotrophic factors involved in the health and survival of neurons, it comes as little surprise that is supports memory and learning. Similar to piracetam, Noopept aids memory formation, but it also has data indicating it may enhance memory consolidation and retrieval, too.
Much of the memory-enhancing research on Noopept have been conducted in patients with brain damage or cognitive decline, including age-related neurodegeneration, stroke, and alcohol-related brain damage.[3,5]
More research is needed investigating the effects of Noopept in healthy populations, but anecdotal reports indicate that Noopept is beneficial for those looking to improve cognitive performance.
Oxidative stress and neuroinflammation are closely linked to age-related cognitive decline and neurodegenerative disorders, including Alzheimer’s disease.
Additionally, chronic systemic inflammation mediates age-related cognitive deficits, including loss of short-term memory, verbal proficiency, learning and executive function.[9,10] Noopept possesses both antioxidant and anti-inflammatory properties which may help combat oxidative damage induced by free radicals.
Moreover, Noopept also helps protect neurons by improving cerebral blood flow and inhibiting neurotoxicity induced by excess glutamate and calcium.
Stress & Anxiety Support
Stress and anxiety levels are at an all-time high these days, with many turning to potentially hazardous chemicals (drugs, alcohol, etc.) for relief. Animal studies suggest that Noopept may help significantly lower anxiety levels.
Additionally, one human study noted that individuals who took 10 mg of Noopept twice daily experienced a reduction in anxiety.
How to Take Noopept
Noopept is typically consumed at a dose of 10mg, one to three times per day. Due to the stimulating nature of noopept, it is recommended not to consume it too close to sleep.
Due to the cholinergic-intensive activities of noopept, it’s typical to dose Noopept alongside a choline-containing supplement, such as Alpha GPC or CDP-Choline.
That’s why we’ve included 600mg of Alpha GPC 50% alongside Noopept in every serving of Overtime. This helps offset any potential choline depletion in the brain, which could lead to headaches and/or brain fog.
- Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. 2008 Sep;146(3):334-7. doi: 10.1007/s10517-008-0297-x. PMID: 19240853.
- Vorobyov V, Kaptsov V, Kovalev G, Sengpiel F. Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors. Brain Res Bull. 2011 May 30;85(3-4):123-32. doi: 10.1016/j.brainresbull.2011.02.011. Epub 2011 Mar 15. PMID: 21414388.
- Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009 Mar;39(3):311-21. doi: 10.1007/s11055-009-9128-4. PMID: 19234797.
- Ostrovskaia RU, Gudasheva TA, Voronina TA, Seredenin SB. [The original novel nootropic and neuroprotective agent noopept]. Eksp Klin Farmakol. 2000a
- Amelin AV, Iliukhina AIu, Shmonin AA. [Noopept in the treatment of mild cognitive impairment in patients with stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(10 Pt 1):44-6. Russian. PMID: 22500312.
- Alekseeva SV, Kovalenko LP, Tallerova AV, Gudasheva TA, Durnev AD. [An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines]. Eksp Klin Farmakol. 2012;75(9):25-7. Russian. PMID: 23156084.
- Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2. PMID: 25096780; PMCID: PMC4422191.
- Heneka MT, Carson MJ, El Khoury J, et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405. doi:10.1016/S1474-4422(15)70016-5
- Lin T, Liu GA, Perez E, et al. Systemic Inflammation Mediates Age-Related Cognitive Deficits. Front Aging Neurosci. 2018;10:236. Published 2018 Aug 6. doi:10.3389/fnagi.2018.00236
- Trollor JN, Smith E, Agars E, et al. The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study. Age (Dordr). 2012;34(5):1295-1308. doi:10.1007/s11357-011-9301-x
- Gudasheva TA, Konstantinopol'skii MA, Ostrovskaya RU, Seredenin SB. Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test. Bull Exp Biol Med. 2001 May;131(5):464-6. doi: 10.1023/a:1017928116025. PMID: 11550054.
- Murzina, G. B., & Pivovarov, A. S. (2019). Modulation of the Acetylcholine-Induced Input Current by Noopept in Helix Lucorum Neurons. Biophysics, 64(3), 393–399. doi:10.1134/s0006350919030151